American Institute of Mathematical Sciences

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August  2003, 3(3): 343-360. doi: 10.3934/dcdsb.2003.3.343

T cell sensitivity and specificity - kinetic proofreading revisited

Cliburn Chan 1, , Andrew J.T. George 1, and  Jaroslav Stark 2,

1. 

Department of Immunology, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, United Kingdom, United Kingdom
2. 

Department of Mathematics, Imperial College London, 180 Queen's Gate, London SW7 2BZ, United Kingdom

Received  June 2002 Revised  February 2003 Published  May 2003

T cells recognise foreign antigen presented by antigen presenting cells at extremely low concentrations, and are able to discriminate between different ligands with high specificity. McKeithan's kinetic proofreading model is often invoked to explain this sensitivity and specificity of the T cell. In this paper, we analyse the strengths and limitations of this model, and suggest that it does not seem adequate to explain the observed degree of T cell sensitivity, specificity and robustness.
Keywords: sensitivity, T cells, robustness., Kinetic proofreading, immunology, specificity.
Mathematics Subject Classification: 92B05, 92C4.
Citation: Cliburn Chan, Andrew J.T. George, Jaroslav Stark. T cell sensitivity and specificity - kinetic proofreading revisited. Discrete and Continuous Dynamical Systems - B, 2003, 3 (3) : 343-360. doi: 10.3934/dcdsb.2003.3.343
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