September  2009, 12(2): 439-453. doi: 10.3934/dcdsb.2009.12.439

Response of yeast mutants to extracellular calcium variations


Division of Mathematical and Natural Sciences, Arizona State University, Phoenix, AZ 85069-7100, United States, United States, United States

Received  October 2008 Revised  May 2009 Published  July 2009

We study, both experimentally and through mathematical modeling, the response of wild type and mutant yeast strains to systematic variations of extracellular calcium abundance. We extend a previously developed mathematical model (Cui and Kaandorp, Cell Calcium, 39, 337 (2006))[3], that explicitly considers the population and activity of proteins with key roles in calcium homeostasis. Modifications of the model can directly address the responses of mutants lacking these proteins. We present experimental results for the response of yeast cells to sharp, step-like variations in external $Ca^{++}$ concentrations. We analyze the properties of the model and use it to simulate the experimental conditions investigated. The model and experiments diverge more markedly in the case of mutants laking the Pmc1 protein. We discuss possible extensions of the model to address these findings.
Citation: Pamela A. Marshall, Eden E. Tanzosh, Francisco J. Solis, Haiyan Wang. Response of yeast mutants to extracellular calcium variations. Discrete and Continuous Dynamical Systems - B, 2009, 12 (2) : 439-453. doi: 10.3934/dcdsb.2009.12.439

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