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Optimisation modelling of cancer growth

  • * Corresponding author: Tiffany A. Jones

    * Corresponding author: Tiffany A. Jones 
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  • Several computational models have been developed in the literature to describe the dynamics of the cell-cycle for the mammalian cell, in particular for cancer cells, using both traditional and new techniques and yielding some positive results. In this paper, we discuss how to optimise model parameters for these types of models and how this can serve to enhance numerical results. We pose the model parameter selection problem as an optimal parameter selection problem on both a normal cell and cancer cell cycle of growth. Various possible objectives are discussed and we illustrate the process with some numerical results.

    Mathematics Subject Classification: Primary:90C90;Secondary:92-08.


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  • Table 1.  Results from MISER3.3 for Multiple Characteristic Time points

    $\mathbf{\zeta}$Initial ValueMISER3.3RoundedTyson
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    Table 2.  Table of $\tau_{i}$ values for characteristic time points

    $ \begin{gathered} \overline {\underline {{\tau _i}\;\;{\text{Times}}} } \hfill \\ {\tau _1}\;\;0 \hfill \\ {\tau _2}\;\;142 \hfill \\ {\tau _3}\;\;284 \hfill \\ {\tau _4}\;\;426 \hfill \\ {\tau _5}\;\;568 \hfill \\ {\tau _6}\;\;710 \hfill \\ {\tau _7}\;\;852 \hfill \\ {\tau _8}\;\;994 \hfill \\ {\tau _9}\;\;1136 \hfill \\ {\tau _{10}}\;\;1278 \hfill \\ \underline {{\tau _{11}}\;\;1420} \hfill \\ \end{gathered} $
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    Table 3.  Table of simulated parameter values

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  •   T. Alarcón , H. M. Byrne  and  P. K. Maini , A mathematical model of the effects of hypoxia on the cell-cycle of normal and cancer cells, JTB, 229 (2004) , 397-411. 
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      T. A. Jones, Mathematical Modelling Of Cancer Growth Ph. D thesis, Curtin University in Bentley, Western Australia, 2014.
      R. C. Loxton , K. L. Teo  and  V. Rehbock , Optimal control problems with multiple characteristic time points in the objective and constraints, Automatica, 44 (2008) , 2923-2929.  doi: 10.1016/j.automatica.2008.04.011.
      R. B. Martin , Optimal control drug scheduling of cancer chemotherapy, Automatica, 28 (1992) , 1113-1123.  doi: 10.1016/0005-1098(92)90054-J.
      R. Martin and K. L. Teo, Optimal Control of Drug Administration in Cancer Chemotherapy World Scientific Publishing Company Pte. Ltd, Singapore, 1994. doi: 10.1142/2048.
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      J. J. Tyson  and  B. Novak , Regulation of the eukaryotic cell cycle: Molecular antagonism, hysteresis, and irreversible transitions, JTB, 210 (2001) , 249-263.  doi: 10.1006/jtbi.2001.2293.
      World Health Organization, Media Centre -Cancer Electronically on World Wide Web, 2012. Available from: http://www.who.int/mediacentre/factsheets/fs297/en/.
      R. A. Weinberg, The Biology of Cancer Garland Science, New York, 2007.
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