American Institute of Mathematical Sciences

January  2021, 26(1): 667-691. doi: 10.3934/dcdsb.2020084

Stationary solutions of a free boundary problem modeling the growth of vascular tumors with a necrotic core

 1 College of Mathematics and Information Science, Jiangxi Normal University, Nanchang 330022, China 2 Department of Applied and Computational Mathematics and Statistics, University of Notre Dame, Notre Dame, IN 46556, USA

Received  September 2019 Revised  November 2019 Published  January 2020

In this paper, we present a rigorous mathematical analysis of a free boundary problem modeling the growth of a vascular solid tumor with a necrotic core. If the vascular system supplies the nutrient concentration $\sigma$ to the tumor at a rate $\beta$, then $\frac{\partial\sigma}{\partial\bf n}+\beta(\sigma-\bar\sigma) = 0$ holds on the tumor boundary, where $\bf n$ is the unit outward normal to the boundary and $\bar\sigma$ is the nutrient concentration outside the tumor. The living cells in the nonnecrotic region proliferate at a rate $\mu$. We show that for any given $\rho>0$, there exists a unique $R\in(\rho, \infty)$ such that the corresponding radially symmetric solution solves the steady-state necrotic tumor system with necrotic core boundary $r = \rho$ and outer boundary $r = R$; moreover, there exist a positive integer $n^{**}$ and a sequence of $\mu_n$, symmetry-breaking stationary solutions bifurcate from the radially symmetric stationary solution for each $\mu_n$ (even $n\ge n^{**})$.

Citation: Huijuan Song, Bei Hu, Zejia Wang. Stationary solutions of a free boundary problem modeling the growth of vascular tumors with a necrotic core. Discrete & Continuous Dynamical Systems - B, 2021, 26 (1) : 667-691. doi: 10.3934/dcdsb.2020084
References:

show all references

References:
 [1] Yoichi Enatsu, Emiko Ishiwata, Takeo Ushijima. Traveling wave solution for a diffusive simple epidemic model with a free boundary. Discrete & Continuous Dynamical Systems - S, 2021, 14 (3) : 835-850. doi: 10.3934/dcdss.2020387 [2] Maho Endo, Yuki Kaneko, Yoshio Yamada. Free boundary problem for a reaction-diffusion equation with positive bistable nonlinearity. Discrete & Continuous Dynamical Systems - A, 2020, 40 (6) : 3375-3394. doi: 10.3934/dcds.2020033 [3] Chueh-Hsin Chang, Chiun-Chuan Chen, Chih-Chiang Huang. Traveling wave solutions of a free boundary problem with latent heat effect. Discrete & Continuous Dynamical Systems - B, 2021  doi: 10.3934/dcdsb.2021028 [4] Kuo-Chih Hung, Shin-Hwa Wang. Classification and evolution of bifurcation curves for a porous-medium combustion problem with large activation energy. Communications on Pure & Applied Analysis, , () : -. doi: 10.3934/cpaa.2020281 [5] Lei Yang, Lianzhang Bao. Numerical study of vanishing and spreading dynamics of chemotaxis systems with logistic source and a free boundary. Discrete & Continuous Dynamical Systems - B, 2021, 26 (2) : 1083-1109. doi: 10.3934/dcdsb.2020154 [6] Xinfu Chen, Huiqiang Jiang, Guoqing Liu. Boundary spike of the singular limit of an energy minimizing problem. Discrete & Continuous Dynamical Systems - A, 2020, 40 (6) : 3253-3290. doi: 10.3934/dcds.2020124 [7] Zhilei Liang, Jiangyu Shuai. Existence of strong solution for the Cauchy problem of fully compressible Navier-Stokes equations in two dimensions. Discrete & Continuous Dynamical Systems - B, 2020  doi: 10.3934/dcdsb.2020348 [8] Ali Mahmoodirad, Harish Garg, Sadegh Niroomand. Solving fuzzy linear fractional set covering problem by a goal programming based solution approach. Journal of Industrial & Management Optimization, 2020  doi: 10.3934/jimo.2020162 [9] Elena Nozdrinova, Olga Pochinka. Solution of the 33rd Palis-Pugh problem for gradient-like diffeomorphisms of a two-dimensional sphere. Discrete & Continuous Dynamical Systems - A, 2021, 41 (3) : 1101-1131. doi: 10.3934/dcds.2020311 [10] Marco Ghimenti, Anna Maria Micheletti. Compactness results for linearly perturbed Yamabe problem on manifolds with boundary. Discrete & Continuous Dynamical Systems - S, 2020  doi: 10.3934/dcdss.2020453 [11] Qianqian Hou, Tai-Chia Lin, Zhi-An Wang. On a singularly perturbed semi-linear problem with Robin boundary conditions. Discrete & Continuous Dynamical Systems - B, 2021, 26 (1) : 401-414. doi: 10.3934/dcdsb.2020083 [12] Yangjian Sun, Changjian Liu. The Poincaré bifurcation of a SD oscillator. Discrete & Continuous Dynamical Systems - B, 2021, 26 (3) : 1565-1577. doi: 10.3934/dcdsb.2020173 [13] Shenglan Xie, Maoan Han, Peng Zhu. A posteriori error estimate of weak Galerkin fem for second order elliptic problem with mixed boundary condition. Discrete & Continuous Dynamical Systems - B, 2020  doi: 10.3934/dcdsb.2020340 [14] Yi Zhou, Jianli Liu. The initial-boundary value problem on a strip for the equation of time-like extremal surfaces. Discrete & Continuous Dynamical Systems - A, 2009, 23 (1&2) : 381-397. doi: 10.3934/dcds.2009.23.381 [15] Amru Hussein, Martin Saal, Marc Wrona. Primitive equations with horizontal viscosity: The initial value and The time-periodic problem for physical boundary conditions. Discrete & Continuous Dynamical Systems - A, 2020  doi: 10.3934/dcds.2020398 [16] Mehdi Badsi. Collisional sheath solutions of a bi-species Vlasov-Poisson-Boltzmann boundary value problem. Kinetic & Related Models, 2021, 14 (1) : 149-174. doi: 10.3934/krm.2020052 [17] Kazunori Matsui. Sharp consistency estimates for a pressure-Poisson problem with Stokes boundary value problems. Discrete & Continuous Dynamical Systems - S, 2021, 14 (3) : 1001-1015. doi: 10.3934/dcdss.2020380 [18] Laurence Cherfils, Stefania Gatti, Alain Miranville, Rémy Guillevin. Analysis of a model for tumor growth and lactate exchanges in a glioma. Discrete & Continuous Dynamical Systems - S, 2020  doi: 10.3934/dcdss.2020457 [19] Jianquan Li, Xin Xie, Dian Zhang, Jia Li, Xiaolin Lin. Qualitative analysis of a simple tumor-immune system with time delay of tumor action. Discrete & Continuous Dynamical Systems - B, 2020  doi: 10.3934/dcdsb.2020341 [20] Min Xi, Wenyu Sun, Jun Chen. Survey of derivative-free optimization. Numerical Algebra, Control & Optimization, 2020, 10 (4) : 537-555. doi: 10.3934/naco.2020050

2019 Impact Factor: 1.27

Metrics

• HTML views (434)
• Cited by (0)

• on AIMS