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Modeling drug-protein dynamics

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  • In this paper we discuss two models involving protein binding. The first model describes a system involving a drug, a receptor and a protein, and the question is to what extent the affinity of the drug to the protein affects the drug-receptor binding and thereby the efficiency of the drug. The second model is the basic model underlying Target-Mediated Drug Disposition, which describes the pharmacokinetics of a drug in the presence of a target, often a receptor.
    Mathematics Subject Classification: Primary: 34C20, 34D15; Secondary: 92C42, 92C45, 80A30.

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