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July  2008, 4(3): 453-475. doi: 10.3934/jimo.2008.4.453

An on-line adaptive radiation therapy system for intensity modulated radiation therapy: An application of multi-objective optimization

Danthai Thongphiew 1, , Vira Chankong 1, , Fang-Fang Yin 2, and  Q. Jackie Wu 2,

1. 

Dept Elect. Engin. & Computer Science, Case Western Reserve University, Cleveland, OH, United States, United States
2. 

Department of Radiation Oncology, Duke University Medical Center, Durham, NC, United States, United States

Received  September 2007 Revised  May 2008 Published  July 2008

Radiation therapy (RT) is a non-invasive and highly effective treatment option for Prostate cancer. The goal is to deliver the prescription dose to the tumor (prostate) while minimizing the damages to the surrounding healthy organs namely bladder, rectum, and femoral heads. One major drawback of the conventional RT is that organ positions and shapes vary from day to day and that the original plan that is based on pre-treatment CT images may no longer be appropriate for treatment in subsequent sessions. The usual remedy is to include some margins surrounding the target when planning the treatment. Though this image guided radiation therapy technique allows in-room correction and can eliminate patient setup errors, the uncertainty due to organ deformation still remains. Performing a plan re-optimization will take about 30 minutes which makes it impractical to perform an online correction. In this paper, we develop an Adaptive Radiation Therapy (ART) system for online adaptive IMRT planning to compensate for the internal motion during the course of the prostate cancer treatment. It allows the treatment plan to be quickly modified based on the anatomy-of-the-day.
Keywords: Multi-Leaf Collimator, Intensity Modulated Radiation Therapy, intensity map (fluence map)., Adaptive Radiation therapy, deformable registration.
Mathematics Subject Classification: Primary: 58F15, 58F17; Secondary: 53C3.
Citation: Danthai Thongphiew, Vira Chankong, Fang-Fang Yin, Q. Jackie Wu. An on-line adaptive radiation therapy system for intensity modulated radiation therapy: An application of multi-objective optimization. Journal of Industrial and Management Optimization, 2008, 4 (3) : 453-475. doi: 10.3934/jimo.2008.4.453
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