American Institute of Mathematical Sciences

Advanced
July  2008, 4(3): 453-475. doi: 10.3934/jimo.2008.4.453

An on-line adaptive radiation therapy system for intensity modulated radiation therapy: An application of multi-objective optimization

Danthai Thongphiew 1, , Vira Chankong 1, , Fang-Fang Yin 2, and  Q. Jackie Wu 2,

1. 

Dept Elect. Engin. & Computer Science, Case Western Reserve University, Cleveland, OH, United States, United States
2. 

Department of Radiation Oncology, Duke University Medical Center, Durham, NC, United States, United States

Received  September 2007 Revised  May 2008 Published  July 2008

Radiation therapy (RT) is a non-invasive and highly effective treatment option for Prostate cancer. The goal is to deliver the prescription dose to the tumor (prostate) while minimizing the damages to the surrounding healthy organs namely bladder, rectum, and femoral heads. One major drawback of the conventional RT is that organ positions and shapes vary from day to day and that the original plan that is based on pre-treatment CT images may no longer be appropriate for treatment in subsequent sessions. The usual remedy is to include some margins surrounding the target when planning the treatment. Though this image guided radiation therapy technique allows in-room correction and can eliminate patient setup errors, the uncertainty due to organ deformation still remains. Performing a plan re-optimization will take about 30 minutes which makes it impractical to perform an online correction. In this paper, we develop an Adaptive Radiation Therapy (ART) system for online adaptive IMRT planning to compensate for the internal motion during the course of the prostate cancer treatment. It allows the treatment plan to be quickly modified based on the anatomy-of-the-day.
Keywords: Multi-Leaf Collimator, Intensity Modulated Radiation Therapy, intensity map (fluence map)., Adaptive Radiation therapy, deformable registration.
Mathematics Subject Classification: Primary: 58F15, 58F17; Secondary: 53C3.
Citation: Danthai Thongphiew, Vira Chankong, Fang-Fang Yin, Q. Jackie Wu. An on-line adaptive radiation therapy system for intensity modulated radiation therapy: An application of multi-objective optimization. Journal of Industrial & Management Optimization, 2008, 4 (3) : 453-475. doi: 10.3934/jimo.2008.4.453
[1]

Subhadip Paul, Prasun Kumar Roy. The consequence of day-to-day stochastic dose deviation from the planned dose in fractionated radiation therapy. Mathematical Biosciences & Engineering, 2016, 13 (1) : 159-170. doi: 10.3934/mbe.2016.13.159
[2]

Kateřina Škardová, Tomáš Oberhuber, Jaroslav Tintěra, Radomír Chabiniok. Signed-distance function based non-rigid registration of image series with varying image intensity. Discrete & Continuous Dynamical Systems - S, 2021, 14 (3) : 1145-1160. doi: 10.3934/dcdss.2020386
[3]

Chanh Kieu, Quan Wang. On the scale dynamics of the tropical cyclone intensity. Discrete & Continuous Dynamical Systems - B, 2018, 23 (8) : 3047-3070. doi: 10.3934/dcdsb.2017196
[4]

Guangying Lv, Hongjun Gao, Jinlong Wei, Jiang-Lun Wu. The effect of noise intensity on parabolic equations. Discrete & Continuous Dynamical Systems - B, 2020, 25 (5) : 1715-1728. doi: 10.3934/dcdsb.2019248
[5]

Yunmei Chen, Jiangli Shi, Murali Rao, Jin-Seop Lee. Deformable multi-modal image registration by maximizing Rényi's statistical dependence measure. Inverse Problems & Imaging, 2015, 9 (1) : 79-103. doi: 10.3934/ipi.2015.9.79
[6]

Anatoli F. Ivanov. On global dynamics in a multi-dimensional discrete map. Conference Publications, 2015, 2015 (special) : 652-659. doi: 10.3934/proc.2015.0652
[7]

Sandrine Anthoine, Jean-François Aujol, Yannick Boursier, Clothilde Mélot. Some proximal methods for Poisson intensity CBCT and PET. Inverse Problems & Imaging, 2012, 6 (4) : 565-598. doi: 10.3934/ipi.2012.6.565
[8]

Dana Paquin, Doron Levy, Lei Xing. Multiscale deformable registration of noisy medical images. Mathematical Biosciences & Engineering, 2008, 5 (1) : 125-144. doi: 10.3934/mbe.2008.5.125
[9]

Dana Paquin, Doron Levy, Lei Xing. Hybrid multiscale landmark and deformable image registration. Mathematical Biosciences & Engineering, 2007, 4 (4) : 711-737. doi: 10.3934/mbe.2007.4.711
[10]

Cristian Morales-Rodrigo. A therapy inactivating the tumor angiogenic factors. Mathematical Biosciences & Engineering, 2013, 10 (1) : 185-198. doi: 10.3934/mbe.2013.10.185
[11]

Yachun Li, Shengguo Zhu. Existence results for compressible radiation hydrodynamic equations with vacuum. Communications on Pure & Applied Analysis, 2015, 14 (3) : 1023-1052. doi: 10.3934/cpaa.2015.14.1023
[12]

Tai-Chia Lin, Tsung-Fang Wu. Multiple positive solutions of saturable nonlinear Schrödinger equations with intensity functions. Discrete & Continuous Dynamical Systems, 2020, 40 (4) : 2165-2187. doi: 10.3934/dcds.2020110
[13]

Baba Issa Camara, Houda Mokrani, Evans K. Afenya. Mathematical modeling of glioma therapy using oncolytic viruses. Mathematical Biosciences & Engineering, 2013, 10 (3) : 565-578. doi: 10.3934/mbe.2013.10.565
[14]

Manuel Delgado, Cristian Morales-Rodrigo, Antonio Suárez. Anti-angiogenic therapy based on the binding to receptors. Discrete & Continuous Dynamical Systems, 2012, 32 (11) : 3871-3894. doi: 10.3934/dcds.2012.32.3871
[15]

Daniel Fusca. The Madelung transform as a momentum map. Journal of Geometric Mechanics, 2017, 9 (2) : 157-165. doi: 10.3934/jgm.2017006
[16]

Lluís Alsedà, Michał Misiurewicz. Semiconjugacy to a map of a constant slope. Discrete & Continuous Dynamical Systems - B, 2015, 20 (10) : 3403-3413. doi: 10.3934/dcdsb.2015.20.3403
[17]

Richard Evan Schwartz. Outer billiards and the pinwheel map. Journal of Modern Dynamics, 2011, 5 (2) : 255-283. doi: 10.3934/jmd.2011.5.255
[18]

Valentin Ovsienko, Richard Schwartz, Serge Tabachnikov. Quasiperiodic motion for the pentagram map. Electronic Research Announcements, 2009, 16: 1-8. doi: 10.3934/era.2009.16.1
[19]

John Erik Fornæss, Brendan Weickert. A quantized henon map. Discrete & Continuous Dynamical Systems, 2000, 6 (3) : 723-740. doi: 10.3934/dcds.2000.6.723
[20]

Zenonas Navickas, Rasa Smidtaite, Alfonsas Vainoras, Minvydas Ragulskis. The logistic map of matrices. Discrete & Continuous Dynamical Systems - B, 2011, 16 (3) : 927-944. doi: 10.3934/dcdsb.2011.16.927

2020 Impact Factor: 1.801

Tools

Metrics

  • PDF downloads (58)
  • HTML views (0)
  • Cited by (1)

Other articles
by authors

[Back to Top]

Copyright © 2022 American Institute of Mathematical Sciences | Privacy Policy