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2005, 2(2): 363-380. doi: 10.3934/mbe.2005.2.363

A mathematical model for treatment-resistant mutations of HIV

Helen Moore 1, and  Weiqing Gu 2,

1. 

American Institute of Mathematics, 360 Portage Avenue, Palo Alto, CA 94306, United States
2. 

Department of Mathematics, Harvey Mudd College, 1250 N. Dartmouth Avenue, Claremont, CA 91711, United States

Received  September 2004 Revised  March 2005 Published  March 2005

In this paper, we propose and analyze a mathematical model, in the form of a system of ordinary differential equations, governing mutated strains of human immunodeficiency virus (HIV) and their interactions with the immune system and treatments. Our model incorporates two types of resistant mutations: strains that are not responsive to protease inhibitors, and strains that are not responsive to reverse transcriptase inhibitors. It also includes strains that do not have either of these two types of resistance (wild-type virus) and strains that have both types. We perform our analysis by changing the system of ordinary differential equations (ODEs) to a simple single-variable ODE, then identifying equilibria and determining stability. We carry out numerical calculations that illustrate the behavior of the system. We also examine the effects of various treatment regimens on the development of treatment-resistant mutations of HIV in this model.
Keywords: differential equations, human immunodeficiency virus (HIV), dynam- ics, mathematical modeling, treatment-resistant mutations., T cells.
Mathematics Subject Classification: 37N2.
Citation: Helen Moore, Weiqing Gu. A mathematical model for treatment-resistant mutations of HIV. Mathematical Biosciences & Engineering, 2005, 2 (2) : 363-380. doi: 10.3934/mbe.2005.2.363
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