2005, 2(3): 445-460. doi: 10.3934/mbe.2005.2.445

Interstitial Pressure And Fluid Motion In Tumor Cords

1. 

Istituto di Analisi dei Sistemi ed Informatica ''A. Ruberti", CNR, Viale Manzoni 30, 00185 Roma, Italy, Italy, Italy

2. 

Dipartimento di Matematica "U. Dini", Università di Firenze, Viale Morgagni 67/A, 50134 Firenze

Received  January 2005 Revised  June 2005 Published  August 2005

This work illustrates the behavior of the interstitial pressure and of the interstitial fluid motion in tumor cords (cylindrical arrangements of tumor cells growing around blood vessels of the tumor) by means of numerical simulations on the basis of a mathematical model previously developed. The model describes the steady state of a tumor cord surrounded by necrosis and its time evolution following cell killing. The most relevant aspects of the dynamics of extracellular fluid are by computing the longitudinal average of the radial fluid velocity and of the pressure field. In the present paper, the necrotic region is treated as a mixture of degrading dead cells and fluid.
Citation: Alessandro Bertuzzi, Antonio Fasano, Alberto Gandolfi, Carmela Sinisgalli. Interstitial Pressure And Fluid Motion In Tumor Cords. Mathematical Biosciences & Engineering, 2005, 2 (3) : 445-460. doi: 10.3934/mbe.2005.2.445
[1]

Zejia Wang, Suzhen Xu, Huijuan Song. Stationary solutions of a free boundary problem modeling growth of angiogenesis tumor with inhibitor. Discrete and Continuous Dynamical Systems - B, 2018, 23 (6) : 2593-2605. doi: 10.3934/dcdsb.2018129

[2]

Junde Wu, Shangbin Cui. Asymptotic behavior of solutions for parabolic differential equations with invariance and applications to a free boundary problem modeling tumor growth. Discrete and Continuous Dynamical Systems, 2010, 26 (2) : 737-765. doi: 10.3934/dcds.2010.26.737

[3]

Shihe Xu. Analysis of a delayed free boundary problem for tumor growth. Discrete and Continuous Dynamical Systems - B, 2011, 15 (1) : 293-308. doi: 10.3934/dcdsb.2011.15.293

[4]

Shihe Xu, Yinhui Chen, Meng Bai. Analysis of a free boundary problem for avascular tumor growth with a periodic supply of nutrients. Discrete and Continuous Dynamical Systems - B, 2016, 21 (3) : 997-1008. doi: 10.3934/dcdsb.2016.21.997

[5]

Avner Friedman, Xiulan Lai. Free boundary problems associated with cancer treatment by combination therapy. Discrete and Continuous Dynamical Systems, 2019, 39 (12) : 6825-6842. doi: 10.3934/dcds.2019233

[6]

Junde Wu. Bifurcation for a free boundary problem modeling the growth of necrotic multilayered tumors. Discrete and Continuous Dynamical Systems, 2019, 39 (6) : 3399-3411. doi: 10.3934/dcds.2019140

[7]

Yang Zhang. A free boundary problem of the cancer invasion. Discrete and Continuous Dynamical Systems - B, 2022, 27 (3) : 1323-1343. doi: 10.3934/dcdsb.2021092

[8]

Jian-Guo Liu, Min Tang, Li Wang, Zhennan Zhou. Analysis and computation of some tumor growth models with nutrient: From cell density models to free boundary dynamics. Discrete and Continuous Dynamical Systems - B, 2019, 24 (7) : 3011-3035. doi: 10.3934/dcdsb.2018297

[9]

Shihe Xu, Meng Bai, Fangwei Zhang. Analysis of a free boundary problem for tumor growth with Gibbs-Thomson relation and time delays. Discrete and Continuous Dynamical Systems - B, 2018, 23 (9) : 3535-3551. doi: 10.3934/dcdsb.2017213

[10]

Xu'an Dou, Jian-Guo Liu, Zhennan Zhou. A tumor growth model with autophagy: The reaction-(cross-)diffusion system and its free boundary limit. Discrete and Continuous Dynamical Systems - B, 2022  doi: 10.3934/dcdsb.2022154

[11]

Fujun Zhou, Shangbin Cui. Well-posedness and stability of a multidimensional moving boundary problem modeling the growth of tumor cord. Discrete and Continuous Dynamical Systems, 2008, 21 (3) : 929-943. doi: 10.3934/dcds.2008.21.929

[12]

Andrea Tosin. Multiphase modeling and qualitative analysis of the growth of tumor cords. Networks and Heterogeneous Media, 2008, 3 (1) : 43-83. doi: 10.3934/nhm.2008.3.43

[13]

J. Ignacio Tello. On a mathematical model of tumor growth based on cancer stem cells. Mathematical Biosciences & Engineering, 2013, 10 (1) : 263-278. doi: 10.3934/mbe.2013.10.263

[14]

Huijuan Song, Bei Hu, Zejia Wang. Stationary solutions of a free boundary problem modeling the growth of vascular tumors with a necrotic core. Discrete and Continuous Dynamical Systems - B, 2021, 26 (1) : 667-691. doi: 10.3934/dcdsb.2020084

[15]

A. Chauviere, L. Preziosi, T. Hillen. Modeling the motion of a cell population in the extracellular matrix. Conference Publications, 2007, 2007 (Special) : 250-259. doi: 10.3934/proc.2007.2007.250

[16]

Ángela Jiménez-Casas, Aníbal Rodríguez-Bernal. PDE problems with concentrating terms near the boundary. Communications on Pure and Applied Analysis, 2020, 19 (4) : 2147-2195. doi: 10.3934/cpaa.2020095

[17]

Peter E. Kloeden, Stefanie Sonner, Christina Surulescu. A nonlocal sample dependence SDE-PDE system modeling proton dynamics in a tumor. Discrete and Continuous Dynamical Systems - B, 2016, 21 (7) : 2233-2254. doi: 10.3934/dcdsb.2016045

[18]

Sandesh Athni Hiremath, Christina Surulescu, Anna Zhigun, Stefanie Sonner. On a coupled SDE-PDE system modeling acid-mediated tumor invasion. Discrete and Continuous Dynamical Systems - B, 2018, 23 (6) : 2339-2369. doi: 10.3934/dcdsb.2018071

[19]

Avner Friedman. Free boundary problems arising in biology. Discrete and Continuous Dynamical Systems - B, 2018, 23 (1) : 193-202. doi: 10.3934/dcdsb.2018013

[20]

Aneta Wróblewska-Kamińska. Local pressure methods in Orlicz spaces for the motion of rigid bodies in a non-Newtonian fluid with general growth conditions. Discrete and Continuous Dynamical Systems - S, 2013, 6 (5) : 1417-1425. doi: 10.3934/dcdss.2013.6.1417

2018 Impact Factor: 1.313

Metrics

  • PDF downloads (44)
  • HTML views (0)
  • Cited by (7)

[Back to Top]