Realization of immune response features by dynamical system models

Mika Yoshida; Kinji Fuchikami; Tatsuya Uezu

doi:10.3934/mbe.2007.4.531

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2007, Volume 4, Issue 3: 531-552. Doi: 10.3934/mbe.2007.4.531

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Realization of immune response features by dynamical system models

1.
Graduate School of Humanities and Sciences, Nara Women's University, Kitauoyahigashi-machi, Nara 630-8506
2.
In-Silico Sciences, Inc., Tokyo 145-0065

Received: April 30, 2006

Revised: December 31, 2006

Published: April 2007

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Abstract

Among the features of real immune responses that occur when antigens invade a body are two remarkable features. One is that the number of antibodies produced in the secondary invasion by identical antigens is more than 10 times larger than in the primary invasion. The other is that more effective antibodies, which are produced by somatic hypermutation during the immune response, can neutralize the antigens more quickly. This phenomenon is called ''affinity maturation''.
In this paper, we try to reproduce these features by dynamical system models and present possible factors to realize them. Further, we present a model in which the memory of the antigen invasion is realized without immune memory cells.

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Mathematics Subject Classification: 37N25.

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