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Abstract
Implantation of drug eluting stents following percutaneous
transluminal angioplasty has revealed a well established
technique for treating occlusions caused by
the atherosclerotic plaque.
However, due to the risk of vascular re-occlusion,
other alternative therapeutic strategies
of drug delivery are currently being investigated.
Polymeric endoluminal pave stenting is an emerging technology
for preventing blood erosion and for optimizing drug release.
The classical and novel methodologies are compared through
a mathematical model able to predict the evolution of
the drug concentration in a cross-section of the wall.
Though limited to an idealized configuration, the present
model is shown to catch most of the relevant aspects of
the drug dynamics in a delivery system.
Results of numerical simulations shows that
a bi-layer gel paved stenting guarantees a uniform drug elution and
a prolonged perfusion
of the tissues, and remains a promising and effective technique
in drug delivery.
Mathematics Subject Classification: Primary: 92B05, 62P10; Secondary: 74S05.
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