American Institute of Mathematical Sciences

Advanced
2011, 8(2): 253-261. doi: 10.3934/mbe.2011.8.253

A mathematical model for chronic wounds

Avner Friedman 1, and  Chuan Xue 2,

1. 

Mathematical Biosciences Institute and Department of Mathematics, Ohio State University, Columbus, OH 43210, United States
2. 

Mathematical Biosciences Institute, Ohio State University, Columbus, OH 43210, United States

Received  March 2010 Revised  August 2010 Published  April 2011

Chronic wounds are often associated with ischemic conditions whereby the blood vascular system is damaged. A mathematical model which accounts for these conditions is developed and computational results are described in the two-dimensional radially symmetric case. Preliminary results for the three-dimensional axially symmetric case are also included.
Keywords: free boundary problem, viscoelasticity., Chronic wound healing.
Mathematics Subject Classification: 92C50, 35R35, 35B4.
Citation: Avner Friedman, Chuan Xue. A mathematical model for chronic wounds. Mathematical Biosciences & Engineering, 2011, 8 (2) : 253-261. doi: 10.3934/mbe.2011.8.253
References:
[1]

C. K. Sen, G. M. Gordillo, S. Roy, R. Kirsner, L. Lambert, T. K Hunt, F. Gottrup, G. C. Gurtner and M. T. Longaker, Human skin wounds: A major and snowballing threat to public health and the economy, Wound Repair Regen., 17 (2009), 763-771. doi: 10.1111/j.1524-475X.2009.00543.x.  Google Scholar

[2]

R. F. Diegelmann and M. C. Evans, Wound healing: An overview of acute, fibrotic and delayed healing, Front Biosci., 9 (2004), 283-289. doi: 10.2741/1184.  Google Scholar

[3]

N. B. Menke, K. R. Ward, T. M. Witten, D. G. Bonchev and R. F. Diegelmann, Impaired wound healing, Clinics in Dermatology, 25 (2007), 19-25. doi: 10.1016/j.clindermatol.2006.12.005.  Google Scholar

[4]

A. J. Singer and R. A. Clark, Cutaneous wound healing, N. Engl. J. Med., 341 (1999), 738-746. doi: 10.1056/NEJM199909023411006.  Google Scholar

[5]

F. Werdin, M. Tennenhaus, H. Schaller and H. Rennekampff, Evidence-based management strategies for treatment of chronic wounds, Eplasty, 9:e19, (2009). Google Scholar

[6]

P. D. Dale, J. A. Sherratt and P. K. Maini, A mathematical model for collagen fibre formation during foetal and adult dermal wound healing, Proc. Biol. Sci., 263 (1996), 653-660. doi: 10.1098/rspb.1996.0098.  Google Scholar

[7]

G. J. Pettet, H. M. Byrne, D. L. S. Mcelwain and J. Norbury, A model of wound-healing angiogenesis in soft tissue, Math. Biosci., 136 (1996), 35-63. doi: 10.1016/0025-5564(96)00044-2.  Google Scholar

[8]

G. Pettet, M. A. J. Chaplain, D. L. S. Mcelwain and H. M. Byrne, On the role of angiogenesis in wound healing, Proc. R. Soc. Lond. B, 263 (1996), 1487-1493. doi: 10.1098/rspb.1996.0217.  Google Scholar

[9]

H. M. Byrne, M. A. J. Chaplain, D. L. Evans and I. Hopkinson, Mathematical modelling of angiogenesis in wound healing: Comparison of theory and experiment, J. Theor. Med., 2 (2000), 175-197. doi: 10.1080/10273660008833045.  Google Scholar

[10]

R. C. Schugart, A. Friedman, R. Zhao and C. K. Sen, Wound angiogenesis as a function of tissue oxygen tension: A mathematical model, Proc. Nat. Acad. Sci. U.S.A., 105 (2008), 2628-2633. doi: 10.1073/pnas.0711642105.  Google Scholar

[11]

Y. Dor, V. Djonov and E. Keshet, Induction of vascular networks in adult organs: Implications to proangiogenic therapy, Ann. N.Y. Acad. Sci., 995 (2003), 208-216. doi: 10.1111/j.1749-6632.2003.tb03224.x.  Google Scholar

[12]

Y. Dor, V. Djonov and E. Keshet, Making vascular networks in the adult: Branching morphogenesis without a roadmap, Trends in Cell Biology, 13 (2003), 131-136. doi: 10.1016/S0962-8924(03)00022-9.  Google Scholar

[13]

S. R. McDougall, A. R. A. Anderson, M. A. J. Chaplain and J. A. Sherratt, Mathematical modelling of flow through vascular networks: Implications for tumour-induced angiogenesis and chemotherapy strategies, Bull. Math. Biol., 64 (2002), 673-702. doi: 10.1006/bulm.2002.0293.  Google Scholar

[14]

A. Stephanou, S. R. McDougall, A. R. A. Anderson and M. A. J. Chaplain, Mathematical modelling of flow in 2d and 3d vascular networks: Applications to anti-angiogenic and chemotherapeutic drug strategies, Mathematical and Computer Modelling, 41 (2005), 1137-1156. doi: 10.1016/j.mcm.2005.05.008.  Google Scholar

[15]

A. R. A. Anderson and M. A. J. Chaplain, Continuous and discrete mathematical models of tumor-induced angiogenesis, Bull. Math. Biol., 60 (1998), 857-899. doi: 10.1006/bulm.1998.0042.  Google Scholar

[16]

C. Xue, A. Friedman and C. K. Sen, A mathematical model of ischemic cutaneous wounds, Proc. Nat. Acad. Sci. USA, 106 (2009), 16782-16787. doi: 10.1073/pnas.0909115106.  Google Scholar

[17]

A. Friedman, C. Huang and J. Yong, Effective permeability of the boundary of a domain, Comm. Partial Differential Equations, 20 (1995), 59-102.  Google Scholar

[18]

S. Roy, S. Biswas, S. Khanna, G. Gordillo, V. Bergdall, J. Green, C. B. Marsh, L. J. Gould and C. K. Sen, Characterization of a pre-clinical model of chronic ischemic wound, Physiol. Genomics, 37 (2009), 211-224. doi: 10.1152/physiolgenomics.90362.2008.  Google Scholar

[19]

A. Friedman, B. Hu and C. Xue, Analysis of a mathematical model of ischemic cutaneous wounds, SIAM J. Math. Anal., 42 (2010), 2013-2040. doi: 10.1137/090772630.  Google Scholar

show all references

References:
[1]

C. K. Sen, G. M. Gordillo, S. Roy, R. Kirsner, L. Lambert, T. K Hunt, F. Gottrup, G. C. Gurtner and M. T. Longaker, Human skin wounds: A major and snowballing threat to public health and the economy, Wound Repair Regen., 17 (2009), 763-771. doi: 10.1111/j.1524-475X.2009.00543.x.  Google Scholar

[2]

R. F. Diegelmann and M. C. Evans, Wound healing: An overview of acute, fibrotic and delayed healing, Front Biosci., 9 (2004), 283-289. doi: 10.2741/1184.  Google Scholar

[3]

N. B. Menke, K. R. Ward, T. M. Witten, D. G. Bonchev and R. F. Diegelmann, Impaired wound healing, Clinics in Dermatology, 25 (2007), 19-25. doi: 10.1016/j.clindermatol.2006.12.005.  Google Scholar

[4]

A. J. Singer and R. A. Clark, Cutaneous wound healing, N. Engl. J. Med., 341 (1999), 738-746. doi: 10.1056/NEJM199909023411006.  Google Scholar

[5]

F. Werdin, M. Tennenhaus, H. Schaller and H. Rennekampff, Evidence-based management strategies for treatment of chronic wounds, Eplasty, 9:e19, (2009). Google Scholar

[6]

P. D. Dale, J. A. Sherratt and P. K. Maini, A mathematical model for collagen fibre formation during foetal and adult dermal wound healing, Proc. Biol. Sci., 263 (1996), 653-660. doi: 10.1098/rspb.1996.0098.  Google Scholar

[7]

G. J. Pettet, H. M. Byrne, D. L. S. Mcelwain and J. Norbury, A model of wound-healing angiogenesis in soft tissue, Math. Biosci., 136 (1996), 35-63. doi: 10.1016/0025-5564(96)00044-2.  Google Scholar

[8]

G. Pettet, M. A. J. Chaplain, D. L. S. Mcelwain and H. M. Byrne, On the role of angiogenesis in wound healing, Proc. R. Soc. Lond. B, 263 (1996), 1487-1493. doi: 10.1098/rspb.1996.0217.  Google Scholar

[9]

H. M. Byrne, M. A. J. Chaplain, D. L. Evans and I. Hopkinson, Mathematical modelling of angiogenesis in wound healing: Comparison of theory and experiment, J. Theor. Med., 2 (2000), 175-197. doi: 10.1080/10273660008833045.  Google Scholar

[10]

R. C. Schugart, A. Friedman, R. Zhao and C. K. Sen, Wound angiogenesis as a function of tissue oxygen tension: A mathematical model, Proc. Nat. Acad. Sci. U.S.A., 105 (2008), 2628-2633. doi: 10.1073/pnas.0711642105.  Google Scholar

[11]

Y. Dor, V. Djonov and E. Keshet, Induction of vascular networks in adult organs: Implications to proangiogenic therapy, Ann. N.Y. Acad. Sci., 995 (2003), 208-216. doi: 10.1111/j.1749-6632.2003.tb03224.x.  Google Scholar

[12]

Y. Dor, V. Djonov and E. Keshet, Making vascular networks in the adult: Branching morphogenesis without a roadmap, Trends in Cell Biology, 13 (2003), 131-136. doi: 10.1016/S0962-8924(03)00022-9.  Google Scholar

[13]

S. R. McDougall, A. R. A. Anderson, M. A. J. Chaplain and J. A. Sherratt, Mathematical modelling of flow through vascular networks: Implications for tumour-induced angiogenesis and chemotherapy strategies, Bull. Math. Biol., 64 (2002), 673-702. doi: 10.1006/bulm.2002.0293.  Google Scholar

[14]

A. Stephanou, S. R. McDougall, A. R. A. Anderson and M. A. J. Chaplain, Mathematical modelling of flow in 2d and 3d vascular networks: Applications to anti-angiogenic and chemotherapeutic drug strategies, Mathematical and Computer Modelling, 41 (2005), 1137-1156. doi: 10.1016/j.mcm.2005.05.008.  Google Scholar

[15]

A. R. A. Anderson and M. A. J. Chaplain, Continuous and discrete mathematical models of tumor-induced angiogenesis, Bull. Math. Biol., 60 (1998), 857-899. doi: 10.1006/bulm.1998.0042.  Google Scholar

[16]

C. Xue, A. Friedman and C. K. Sen, A mathematical model of ischemic cutaneous wounds, Proc. Nat. Acad. Sci. USA, 106 (2009), 16782-16787. doi: 10.1073/pnas.0909115106.  Google Scholar

[17]

A. Friedman, C. Huang and J. Yong, Effective permeability of the boundary of a domain, Comm. Partial Differential Equations, 20 (1995), 59-102.  Google Scholar

[18]

S. Roy, S. Biswas, S. Khanna, G. Gordillo, V. Bergdall, J. Green, C. B. Marsh, L. J. Gould and C. K. Sen, Characterization of a pre-clinical model of chronic ischemic wound, Physiol. Genomics, 37 (2009), 211-224. doi: 10.1152/physiolgenomics.90362.2008.  Google Scholar

[19]

A. Friedman, B. Hu and C. Xue, Analysis of a mathematical model of ischemic cutaneous wounds, SIAM J. Math. Anal., 42 (2010), 2013-2040. doi: 10.1137/090772630.  Google Scholar

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